(HOW) IT WORKS

Purity. Precision-Enabled. Patient Satisfaction.
Jeuveau® (prabotulinumtoxinA-xvfs) injection is an FDA-approved prescription medicine (AKA neuromodular, AKA neurotoxin, AKA tox) used to temporarily improve the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults.
When expertly injected for frown lines or “11’s”, Jeuveau® temporarily prevents your nerves from telling your muscles to flex or contract. This process smooths the appearance of “dynamic” frown lines — like the ones from years of frowning at your phone.
Model - Soo Youn
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Unlike any other injectable neuromodulator, Jeuveau® is made with proprietary

Hi-Pure™ Technology.

Our manufacturing process works to purify the product, ultimately helping practitioners artfully inject Jeuveau® with precision, achieving precise, natural-looking results you’ll love.
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Proven results = Patient satisfaction

In U.S. clinical studies, 68% and 70% of Jeuveau® patients had a 2-grade or better physician- and patient-rated improvement in moderate to severe frown lines at Day 30 as compared to 1% for placebo.3 (In regular English? Both injectors and patients saw significantly improved results 30 days after treatment.)
Model posing. Mia

Does Jeuveau® work as well as Botox® Cosmetic?

In the largest head-to-head phase III study in frown lines, Jeuveau® demonstrated non-inferiority to Botox Cosmetic®.*
But that's not all, in the same study, which was conducted in Europe and Canada, 54% of patients had visible results with at least a 1-grade improvement as early as 2 days after treatment.** And at an impressive 4 months after treatment, 58% of patients still had visible results with Jeuveau®.***
*A non-inferiority study is conducted to show that the effect of a treatment is not worse than the original treatment.
**About 50% of patients begin showing improvement after two days (≥1-grade improvement by physician assessment).2 Most patients (~69%) achieve complete results by day 30 (≥2-grade improvement by physician and patient assessments).3
***Compared to 13% placebo, based on ≥ 1-grade improvement by physician assessment at Day 120.2 Results based on a 1-grade improvement may not be considered clinically meaningful. On average, Jeuveau® patients receive 3 treatments a year.1
Botox® Cosmetic is prescription medicine that is injected into muscles and used to temporarily improve the look of moderate to severe frown lines between the eyebrows in adults. BOTOX is a registered trademark of Allergan, Inc.
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4 REASONS TO CHOOSE Jeuveau®

prabotulinumtoxinA-xvfs
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10-minute
Treatment
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NATURAL-LOOKING
Results
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Lasts up to
4 months
On average, Jeuveau® patients receive 3 treatments a year.1
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fast
Acting
About 50% of patients had visible improvement after 2 days ( ≥ 1-grade improvement)2. Most patients (~69%) achieved complete results after 30 days( ≥ 2-grade improvement).3

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‍SHOW & TELL

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Soo YOUn
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Model. Arielle. Portait
arielle
Model. Tajah. Portait
tajah
Model. Sarah. Portait
sarah
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FREQUENTLY ASKED QUESTIONS

(Apart from “How soon can I book?”)
What exactly is Jeuveau (prabotulinumtoxinA-xvfs)?
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You know those pesky little wrinkles between your eyebrows that won’t go away? Well, they're called glabellar lines, also referred to as "frown lines" or "elevens." Jeuveau is a prescription injectable treatment that works to temporarily improve the appearance of moderate to severe frown lines in adults.

How does Jeuveau work?
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When injected, Jeuveau temporarily prevents your nerves from telling your facial muscles to flex. The result? In clinical trials, Jeuveau was shown to temporarily improve the appearance of moderate to severe frown lines.

What are the results with Jeuveau?
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In clinical trials, Jeuveau was shown to temporarily improve the appearance of moderate to severe frown lines. In US studies, 68% and 70% of Jeuveau patients had a 2-grade or better physician- and patient-rated improvement in frown lines at Day 30. But that's not all. In a study conducted in Europe and Canada, 54% of patients had visible results as early as 2 days after treatment.* And at 5 months after treatment, 38% of patients had visible results with Jeuveau**

*54% of Jeuveau patients had a ≥1-grade improvement in frown lines at Day 2 based on physician assessment compared to 12% for placebo (secondary endpoint). In US studies, 46% and 56% had a ≥1-grade improvement in frown lines at Day 2 based on physician assessment compared to 8% and 17% for placebo (exploratory endpoint). Results based on a 1-grade improvement may not be clinically meaningful.

*38% of Jeuveau patients had a ≥1-grade improvement in frown lines at 5 months based on physician assessment compared to 8% for placebo (secondary endpoint). In US studies, almost 5% of patients had a ≥2-grade improvement in frown lines at 5 months based on both patient and physician assessments compared to 0% for placebo (secondary endpoint). Results after day 30 or based on a 1-grade improvement may not be clinically meaningful.

What’s it like before & after treatment?
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If it’s your first time getting a treatment, you may be a little nervous and that’s okay! Localized pain, infection, inflammation, tenderness, swelling, erythema, and/or bleeding/bruising may be associated with the injection. For specific instructions on what to do before and after your treatment, please follow the instructions as given to you by your doctor or healthcare provider.

What should I tell my doctor before getting treatment with Jeuveau?
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Tell your healthcare provider about all your muscle or nerve conditions, such as ALS or Lou Gehrig’s disease, Myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of serious side effects including difficulty swallowing and difficulty breathing from typical doses of Jeuveau.

Tell your healthcare provider about all your medical conditions, including: any side effects from botulinum toxin products, including dry eye; breathing, swallowing, bleeding, or heart problems; plans to have surgery; weakness of forehead muscles; drooping eyelids; have had surgery on your face; are pregnant or breastfeeding or plan to become pregnant or breastfeed (it is not known if Jeuveau can harm your unborn baby or passes into breast milk).

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using Jeuveau with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your healthcare provider that you have received Jeuveau in the past.

Especially tell your healthcare provider if you: have received any other botulinum toxin product in the past and the last 4 months, and exactly which product you received (such as BOTOX, BOTOX Cosmetic, MYOBLOC, DYSPORT, or XEOMIN).

What are the possible side effects of Jeuveau?
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No serious or drug-related adverse events were observed in the Jeuveau clinical studies.

Jeuveau may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems any time (hours to weeks) after injection of Jeuveau:

  • Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.
  • Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.

Jeuveau can cause other serious side effects including:

  • Allergic reactions such as itching, rash, red itchy welts, wheezing, trouble breathing, asthma symptoms, or dizziness or feeling faint. Tell your healthcare provider or get emergency medical help right away if you develop wheezing or trouble breathing, or if you feel dizzy or faint.
  • Heart problems. Irregular heartbeat and heart attack that have caused death, have happened in some people who received botulinum toxin products.
  • Eye problems such as dry eye, reduced blinking, and corneal problems. Tell your healthcare provider if you develop eye pain or irritation, sensitivity to light, or changes in your vision.

The most common side effects of Jeuveau include headache, eyelid drooping, upper respiratory infection, and increased white blood cell count.

These are not all the possible side effects of Jeuveau. Call your doctor for medical advice about side effects. You may report side effects to FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Where can I find Jeuveau?
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We thought you might ask that. Jeuveau is available at select practices throughout the country.

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Jeuveau® is a prescription medicine that is injected into muscles and used in adults for a short period of time (temporary) to improve the look of moderate to severe frown lines between the eyebrows (glabellar lines).
1. Jeuveau (package insert). Newport Beach, CA :Evolus, Inc. 2020
2. Rzany B. A multicenter, randomized, double-blind, placebo-controlled, single-dose, phase III, non-inferiority study comparing prabotulinumtoxinA and onabotulinumtoxinA for the treatment of moderate to severe glabellar lines in adult patients. Aesthet Surg J. 2020;40(4):413-429.
3. Beer K. Efficacy and safety of prabotulinumtoxinA for the treatment of glabellar lines in adult subjects: results from identical phase III studies. Dermatol Surg. 2019;45(11):1381-1393
4. Kim CS, Song KY, Min KM, An YD, inventors; Daewoong Co, Ltd, assignee. Method for production of botulinum toxin. US patent 9,512,418 B2. December 6, 2016.
5. Jeuveau Experience Treatment (J.E.T.) Interim Data Report, 12/16/2019; Evolus, Inc.