Exclusively licensed and manufactured for: Evolus, Inc., 520 Newport Center Drive, Suite 1200, Newport Beach, CA 92660

PDCR 2020-02-005

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What exactly is Jeuveau®?

You know those pesky little wrinkles between your eyebrows that won’t go away? Well, they’re called glabellar lines, or “frown lines.” Jeuveau® is an injectable treatment that works to temporarily improve the appearance of moderate to severe frown lines in adults.

How does Jeuveau® work?

When injected, Jeuveau® temporarily prevents your nerves from telling your facial muscles to flex. The result? In clinical trials, Jeuveau® was shown to temporarily improve the appearance of moderate to severe frown lines.

What are the results with Jeuveau®?

In clinical trials, Jeuveau® was shown to temporarily improve the appearance of moderate to severe frown lines. In US studies, 68% and 70% of Jeuveau® patients had a 2-grade or better physician and patient-rated improvement in frown lines at Day 30. But that's not all. In a study conducted in Europe and Canada, 54% of patients had visible results as early as 2 days after treatment.* And at 5 months after treatment, 38% of patients had visible results with Jeuveau® **

* 54% of patients had a >1-grade improvement in frown lines at Day 2 based on physician assessment compared to 12% for placebo (secondary endpoint). In US studies, 46% and 56% had a >1-grade improvement in frown lines at Day 2 based on physician-assessment compared to 8% and 17% for placebo (exploratory endpoint). Results based on a 1-grade improvement may not be considered clinically meaningful.

** 38% of patients had a >1-grade improvement in frown lines at 5 months based on physician assessment compared to 8% for placebo (secondary endpoint). In US studies, almost 5% of patients had a >2-grade improvement in frown lines at 5 months based on both patient and physician assessments compared to 0% for placebo (secondary endpoint). Results based on a 1-grade improvement may not be considered clinically meaningful.

What’s it like before & after treatment?

If it’s your first time getting a treatment, you may be a little nervous and that’s okay! Localized pain, infection, inflammation, tenderness, swelling, erythema, and/or bleeding/bruising may be associated with the injection.

For specific instructions on what to do before and after your injection, please follow the instructions as given to you by your doctor or healthcare provider.

What are the side effects?

The most common side effects of Jeuveau® include: headache, eyelid dropping, upper respiratory infection, and increased white blood cell count. These are not all the possible side effects of Jeuveau®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. No serious drug-related adverse events were observed in the studies.

Where can I find Jeuveau®?

We thought you might ask that. Jeuveau® is available at select practices throughout the country. Find a Specialist here.


Jeuveau® is a prescription medicine that is injected into muscles and used in adults for a short period of time (temporary) to improve the look of moderate to severe frown lines between the eyebrows (glabellar lines).

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IMPORTANT SAFETY INFORMATION FOR JEUVEAU® (prabotulinumtoxinA-xvfs)

JEUVEAU® may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems any time (hours to weeks) after injection of JEUVEAU®:
Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.
Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.